JWH - 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55, 212 - 2 . The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9. 0 and 2. 94 nM, respectively, for a CB1: CB2 ratio of 3. 06. 1 Its effects on suppression of spontaneous activity, the maximum possible antinociceptive effect in the tail - flick assay, and rectal temperature are comparable to those of WIN 55 , 212 - 2 when tested in rats.
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