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INTRODUCTIONENZYMES: PENICILLIN G ACYLASE

Both 6-Aminopenicillanic acid (6-APA) and 7-Aminodeacetoxycephalosporanic acid (7-ADCA) are key intermediates used for the production of semi-synthetic Penicillins and Cephalosporins.

Some years ago 6-APA and 7-ADCA were predominantly produced by chemical means. This method was associated with a number of complex technical requirements, and used materials that caused environmental pollution as well as producing unwanted impurities in the product.

The Enzyme route, which is used as an alternative, provides many advantages over the chemical route that includes:

Reduced reaction time - increased operating efficiency
Specificity - the production of unwanted by-products is avoided and there is no need to extensively refine and purify the desired product
Cost saving - enzymes can be immobilized and therefore re-used several times, providing valuable cost savings
Environmentally friendly - enzymes are non corrosive and fully biodegradable

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