DI CALCIUM PHOSPHATE DIHYDRATE

1. Di Calcium Phosphate Dihydrate (Milled)
2. Di Calcium Phosphate Dihydrate (Unmilled)
3. Di Calcium Phosphate Dihydrate (Directly Compressible)

Wet Granulation

For wet granulation Di Calcium Phosphate Dihydrate (Milled) is used.

Wet granulation continues to be a widely used method in the manufacture of Tablets. In this process, granules are formed from wetted mixtures of the pre-blended tablet ingredients (usually milled form of active ingredients plus excipients), dried, screened and compressed into tablets. This method is often employed in tablets that have either a low dose active or a very high dose of actives.

Direct Compression

For direct compression following grades of DCP are used.
Di Calcium Phosphate Dihydrate (Directly Compressible)
Di Calcium Phosphate Dihydrate (Unmilled)

In this process, active ingredients and excipients (D.C. form) are blended and compressed directly. It is the most widely accepted, less elaborate, most economical way of production.

Advantages of direct compression are as under:

• Reduced investment
• Reduced production cost
• Reduced friability
• Reduces time
• Saves energy due to elimination of heat and moisture and simpler production steps, thus stability in the final product.