Carbonate Resin

SP-Carbonate can be used as a general base to quench organic reactions, and neutralize amine-acid salts such as hydrochlorides, sulfonates and trifluoroacetates. SP-Carbonate is very useful for free basing alkylammonium salts, e.g. hydrochlorides and trifluoroacetates. Applications include neutralizing reactants, byproducts and ammonium salts of volatile amines including diisopropylethylamine (DIEA) or triethylamine (TEA). For free basing insoluble ammonium salts, a catalytic amount of DIEA (~0.1 equiv) may be added as a soluble transfer base allowing neutralization and amine removal in the concentration step, circumventing an aqueous workup. SP-Carbonate can scavenge a variety of acidic molecules like carboxylic acids or acidic phenols including HOBt and nitrophenols that generally requires 3-4 equiv of SP-Carbonate. On completion of the scavenging, the product is isolated by filtration and the resin is rinsed 2-3 times with a solvent such as DCM, THF, or EtOH.