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Toxic side effects of local anaesthetic drugs occur when excessive blood levels occur. This is usually due to:
- Accidental rapid intravenous injection.
- Rapid absorption, such as from a very vascular site ie mucous membranes. Intercostal nerve blocks will give a higher blood level than subcutaneous infiltration, whereas plexus blocks are associated with the slowest rates of absorption and therefore give the lowest blood levels.
- Absolute overdose if the dose used is excessive
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Anesthetic drugs